PathwayStep4714 PathwayStep4713 PathwayStep4715 PathwayStep4712 Degradation of multiubiquitinated cell cycle proteins APC/C:Cdh1-mediated degradation of Skp2 Association of cell cycle proteins with the APC/C:Cdh1 complex Ubiquitination of cell cycle proteins targeted by the APC/C:Cdh1complex APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 Edited: Matthews, L, 2006-01-30 00:00:00 From late mitosis through G1 phase APC/C:Cdh1 insures the continued degradation of the mitotic proteins and during mitotic exit and G1 its substrates include Cdc20, Plk1, Aurora A, Cdc6 and Geminin (see Castro et al., 2005). Rape et al. have recently demonstrated that the order in which APC/C targeted proteins are degraded is determined by the processivity of multiubiquitination of these substrates. Processive substrates acquire a polyubiquitin chain upon binding to the APC/C once and are degraded. Distributive substrates bind, dissociate and reassociate with the APC/C multiple times before acquiring an ubiquitin chain of sufficient length to insure degradation. In addition, distributive substrates that dissociate from the APC/C with short ubiquitin chains are targeted for deubiquitination (Rape et al., 2006). GENE ONTOLOGYGO:0031145 Pubmed15678131 Pubmed16413484 Reactome Database ID Release 43174178 Reactome, http://www.reactome.org ReactomeREACT_6761 Reviewed: Peters, JM, 2006-03-27 22:55:09