PathwayStep4709 PathwayStep4708 PathwayStep4710 Association of Cdh1 with the APC/C Dissociation of Cdc20 from APC/C complex Dephosphorylation of phospho-Cdh1 Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Authored: Lorca, T, Castro, A, 2006-01-26 00:00:00 Edited: Matthews, L, 2006-02-17 00:35:21 GENE ONTOLOGYGO:0051439 Pubmed15678131 Reactome Database ID Release 43176407 Reactome, http://www.reactome.org ReactomeREACT_6867 Reviewed: Peters, JM, 2006-03-27 22:55:09 The activity of the APC/C must be appropriately regulated during the cell cycle to ensure the timely degradation of its substrates. Of particular importance is the conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase. Phosphorylation of both the APC/C complex and Cdh1 regulate this conversion. During mitosis, several APC/C subunits are phosphorylated increasing the activity of APC/C:Cdc20. However, phosphorylation of Cdh1 by mitotic Cyclin:Cdk complexes prevents it from activating the APC/C. Dephosphorylation of Cdh1 in late anaphase by Cdc14a results in the activation of APC/C:Cdh1 (reviewed in Castro et al, 2005).