PathwayStep4814 PathwayStep4845 PathwayStep4832 PathwayStep4825 Signal regulatory protein (SIRP) family interactions DSCAM interactions Nephrin interactions Cell junction organization Cell-Cell communication Authored: Garapati, P V, 2011-08-23 Cell-to-Cell communication is crucial for multicellular organisms because it allows organisms to coordinate the activity of their cells. Some cell-to-cell communication requires direct cell-cell contacts and this is mediated by different receptors on their cell surfaces. Members of the immunoglobulin superfamily (IgSF) proteins are some of the cell surface receptors involved in cell-cell recognition, communication and many aspects of the axon guidance and synapse formation-the crucial processes during embryonal development (Rougon & Hobert 2003).<br>Cells interact with adjacent cells as well as with extracellular matrix in tissues and these interactions are supported by cell junctions. Cell junctions consists of protein complexes and include various cell adhesion molecules (CAMs). Cell junctions are more abundant in epithelial cells and there are three major types of cell junctions: adherens junctions (AJs), tight junctions (TJs), and desmosomes. Edited: Garapati, P V, 2011-08-23 Pubmed12598678 Pubmed1616050 Pubmed16691243 Pubmed17766183 Pubmed18837673 Pubmed20554646 Reactome Database ID Release 431500931 Reactome, http://www.reactome.org ReactomeREACT_111155