PathwayStep4757 PathwayStep4758 Incorporation Of Extended And Processed Telomere End Into Higher Order T-Loop And Associated Protein Structure Incorporation Of Extended And Processed Telomere End Into Associated Protein Structure Packaging Of Telomere Ends Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000723 Multiple steps, including C-strand resection, telomerase-mediated elongation, and C-strand synthesis are involved in processing and maintaining the telomere. Though this module posits a linear transit for the steps, in humans it is not well understood how these steps are coordinated and what other events may be involved.<br><br><br>Telomeric DNA can form higher order structures. Electron microscopy of telomeric DNA isolated from human cells provided evidence for lariat-type structures termed telomeric loops, or t-loops (Griffith et al., 1999). t-loops are proposed to result from the invasion of the 3' G-rich single strand overhang into the double stranded telomeric TTAGGG repeat tract. The function of the t-loop is presumed to be the masking of the 3' telomeric overhang. Multiple protein factors can bind telomeric DNA and likely contribute to dynamic, higher order structures.<br> Pubmed10338214 Reactome Database ID Release 43171306 Reactome, http://www.reactome.org ReactomeREACT_7963 Reviewed: Price, C, 2006-07-13 18:33:38