PathwayStep4746 PathwayStep4745 PathwayStep4752 PathwayStep4751 Formation of the Flap Intermediate on the C-strand Formation of C-strand Okazaki fragments Joining of adjacent Okazaki fragments of the C-strand Removal of the Flap Intermediate from the C-strand Processive synthesis on the C-strand of the telomere Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Once polymerase switching from pol alpha to pol delta is complete the processive synthesis of a short run of DNA called an Okazaki fragment begins. DNA synthesis is discontinuous and as the extending Okazaki fragment reaches the RNA primer, this primer is folded into a single-stranded flap, which is removed by endonucleases. The process of extension is completed by the ligation of adjacent Okazaki fragments. Pubmed1671046 Reactome Database ID Release 43174414 Reactome, http://www.reactome.org ReactomeREACT_8027 Reviewed: Price, C, 2006-07-13 18:33:38