PathwayStep4742 PathwayStep4743 PathwayStep4740 PathwayStep4741 RFC dissociates after sliding clamp formation on the C-strand of the telomere Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere RFC binding displaces Pol Alpha on the C-strand of the telomere Formation of Processive Complex on the C-strand of the telomere Polymerase switching on the C-strand of the telomere After the primers are synthesized on the G-Rich strand, Replication Factor C binds to the 3'-end of the initiator DNA to trigger polymerase switching. The non-processive nature of pol alpha catalytic activity and the tight binding of Replication Factor C to the primer-template junction presumably lead to the turnover of the pol alpha:primase complex. After the Pol alpha-primase primase complex is displaced from the primer, the proliferating cell nuclear antigen (PCNA) binds to form a "sliding clamp" structure. Replication Factor C then dissociates, and DNA polymerase delta binds and catalyzes the processive synthesis of DNA. Authored: Blackburn, EH, Seidel, J, 2006-03-09 19:41:08 GENE ONTOLOGYGO:0000722 Pubmed1670772 Pubmed1671046 Pubmed1967833 Reactome Database ID Release 43174411 Reactome, http://www.reactome.org ReactomeREACT_7987 Reviewed: Price, C, 2006-07-13 18:33:38