p-CARMA1 Oligomer CARMA1 oligomer Phosphorylation of CARMA1 in B Cells Authored: May, B, 2010-12-18 CARMA1 is phosphorylated at serines 559, 644, and 652 by Protein Kinase C beta (PKC-beta) (Sommer et al. 2005). CARMA1 is constitutively oligomerized (Tanner et al. 2007) and most CARMA1 in unstimulated cells is cytosolic (Sommer et al. 2005, Tanner et al. 2007), though a portion is constitutively associated with the plasma membrane (Gaide et al. 2002, Sommer et al. 2005). After phosphorylation, CARMA1 is associated with lipid rafts in the plasma membrane (Sommer et al. 2005). Note that some publications refer to CARMA1 with a different N-terminal methionine that is 7 amino acids shorter. In this case the phosphorylated serines are 552, 537, and 645. EC Number: 2.7.11 Edited: May, B, 2010-12-18 Pubmed16356855 Reactome Database ID Release 431168635 Reactome, http://www.reactome.org ReactomeREACT_118598 Reviewed: Wienands, J, 2012-02-11 has a Stoichiometric coefficient of 6