Activated PKC beta Activation of Protein Kinase C beta (PKC-beta) Authored: May, B, 2010-12-09 Edited: May, B, 2010-12-09 Human Protein kinase C beta (PKC-beta) is activated by calcium ions, diacylglycerol, and binds phosphatidylserine (Kochs et al. 1991). Experiments in mice have shown that knocking out PKC-beta causes severe defects in B cells, leading to the conclusion that PKC-beta is the predominant signaling PKC in these cells (Leitges et al. 1996, Su et al. 2002, Saijo et al. 2002). Pubmed12070292 Pubmed12118249 Pubmed8387275 Pubmed8670417 Reactome Database ID Release 431168373 Reactome, http://www.reactome.org ReactomeREACT_118748 Reviewed: Wienands, J, 2012-02-11 has a Stoichiometric coefficient of 3