STIM1 Dimer STIM1:TRPC1 STIM1 Binds TRPC1 Authored: May, B, 2012-01-31 Edited: May, B, 2012-01-31 Formation of STIM1:TRPC1 Complex Pubmed11901194 Pubmed16906149 Pubmed17224452 Pubmed17486119 Pubmed18326500 Pubmed18420269 Pubmed18843204 Pubmed18995841 Pubmed21408196 Pubmed22210847 Reactome Database ID Release 432089927 Reactome, http://www.reactome.org ReactomeREACT_118759 Reviewed: Wienands, J, 2012-02-11 The polybasic region of STIM1 interacts with 2 aspartate residues in the C-terminal region of TRPC1 (Zeng et al. 2008, Huang et al. 2006). The STIM1:TRPC1 complex can form a tenary complex with ORAI1 (Ong et al. 2007, Jardin et al. 2008) and ORAI participates in function of STIM1:TRPC1 channels (Cheng et al. 2008, Cheng et al. 2011). As inferred from chicken DT40 cells, TRPC1 (and possibly other TRP channels) participates in store-operated calcium influx during signaling by the B cell receptor (Mori et al. 2002).