STIM1 Dimer STIM1:Calcium Oligomerization of STIM1 Authored: May, B, 2011-01-19 Edited: May, B, 2011-01-19 In the resting state the luminal domain of STIM1 binds Ca2+ ions within the endoplasmic reticulum and this binding prevents dimerization of STIM1 (Luik et al. 2008). Upon depletion of Ca2+ ions from the endoplasmic reticulum, STIM1 is no longer bound to Ca2+ and forms homodimers (Muik et al. 2008, Luik et al. 2008, Park et al. 2009). Pubmed18187424 Pubmed18596693 Pubmed19249086 Reactome Database ID Release 431168376 Reactome, http://www.reactome.org ReactomeREACT_118808 Reviewed: Wienands, J, 2012-02-11 has a Stoichiometric coefficient of 2