BLNK (SLP-65) Signalosome Generates Diacylglycerol and Inositol-1,4,5-trisphosphate Authored: May, B, 2011-01-19 Edited: May, B, 2011-01-19 Phospholipase C gamma (PLC-gamma) is activated by phosphorylation in response to antigen-binding by the B cell receptor (Carter et al. 1991, Roitman and Wang 1992, Rodriguez et al. 2001, Kim et al. 2004, Sekiya et al. 2004). Phospholipase C gamma hydrolyzes phosphatidylinositol-4,5-bisphosphate to yield inositol-1,4,5-trisphosphate and diacylglycerol (Carter et al. 1991, Kim et al. 2004). Human B cells contain both PLC-gamma1 and PLC-gamma2, with PLC-gamma2 predominating (Coggeshall et al. 1992). Pubmed12181444 Pubmed1374290 Pubmed1376928 Pubmed1599430 Pubmed1705565 Pubmed2011584 Pubmed3500860 Reactome Database ID Release 431112666 Reactome, http://www.reactome.org ReactomeREACT_118781 Reviewed: Wienands, J, 2012-02-11