CD19 Signalosome Generates PIP3 Authored: May, B, 2012-01-10 EC Number: 2.7.1.153 Edited: May, B, 2012-01-10 PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992). Experiments in mice indicate that PI3K associated with CD19 is partly responsible for the activity (Buhl et al. 1997, Otero et al. 2001, Aiba et al. 2008). (PI3K associated with BCAP is also partly responsible (Aiba et al. 2008).) Pubmed11042164 Pubmed1372019 Pubmed18025150 Pubmed9235916 Pubmed9382888 Reactome Database ID Release 432076220 Reactome, http://www.reactome.org ReactomeREACT_118828 Reviewed: Wienands, J, 2012-02-11