BCAP Signalosome Generates PIP3 Authored: May, B, 2012-01-10 Edited: May, B, 2012-01-10 PI3K generates phosphoinositol-3,4,5-trisphosphate (PIP3) from PIP2 after activation of the BCR (Gold et al. 1992, Chantry et al. 1997). Experiments in mice indicate that PI3K associated with BCAP is partly responsible for the activity (Aiba et al. 2008). (PI3K associated with CD19 is also partly responsible (Aiba et al. 2008).) Pubmed1372019 Pubmed18025150 Pubmed9235916 Reactome Database ID Release 432045911 Reactome, http://www.reactome.org ReactomeREACT_118601 Reviewed: Wienands, J, 2012-02-11