PathwayStep4558 PathwayStep4555 PathwayStep4550 Activation of E2F target genes at G1/S E2F-enabled inhibition of pre-replication complex formation Inhibition of replication initiation of damaged DNA by RB1/E2F1 E2F mediated regulation of DNA replication Authored: Gopinathrao, G, 2004-06-16 19:20:00 Progression through G1 and G1 to S-phase transition that initiates DNA synthesis involve many complexes that are regulated by RB1:E2F pathway. RB1:E2F pathway plays a key role in gene expression regulation in proliferating and differentiated cells. As a repressor, E2F remains bound to RB1; it can activate the expression of S-phase genes involved in DNA replication after the phosphorylation of RB1.<BR>E2F proteins regulate expression of genes involved in various processes thereby forming interlinks between cell cycle, DNA synthesis, DNA damage recognition etc.<BR>In this module, activation of replication related genes by E2F1 and two ways by which E2F1 regulates DNA replication initiation are annotated. Detailed connection between the E2F protein function and various pathways will be covered in future releases of Reactome. Pubmed12393009 Pubmed12473340 Pubmed12726857 Reactome Database ID Release 43113510 Reactome, http://www.reactome.org ReactomeREACT_471