Antigen Antigen:BCR BCR The Immunoglobulin of the BCR Binds Antigen Authored: May, B, 2010-09-28 Edited: May, B, 2010-09-28 Mature, unstimulated B cells express IgM and IgD immunoglobulins on their surfaces (Fu et al. 1974, Fu et al. 1975, reviewed in Kunkel 1975). The immunoglobulins form B cell receptor (BCR) complexes with disulfide-linked heterodimers of Ig-alpha (CD79A) and Ig-beta (CD79B), which have cytoplasmic tails containing immunoreceptor tyrosine-based activation motifs (ITAMs) (van Noesel et al. 1992, Saouaf et al. 1995, inferred from mouse Hombach et al. 1990, Wienands et al. 1990). Upon binding of antigen to the immunoglobulin a chain of phosphorylation events is triggered (Nel et al. 1984, Saouaf et al. 1994, Hata et al. 1994, Saouaf et al. 1995, reviewed in Harwood and Batista 2010). Pubmed1081164 Pubmed1375264 Pubmed20192804 Pubmed2303036 Pubmed2304550 Pubmed4589993 Pubmed6335036 Pubmed7524079 Pubmed7592958 Pubmed7927516 Pubmed803528 Reactome Database ID Release 43983696 Reactome, http://www.reactome.org ReactomeREACT_118606 Reviewed: Wienands, J, 2012-02-11 The Immunoglobulin of the B Cell Receptor Binds Antigen