Antigen:p-BCR:SYK Antigen:p-BCR Recruitment of SYK to the Activated BCR Authored: May, B, 2010-10-31 Edited: May, B, 2010-10-31 Pubmed18818202 Pubmed7538118 Pubmed7592958 Pubmed8163536 Reactome Database ID Release 43983700 Reactome, http://www.reactome.org ReactomeREACT_118749 Recruitment of SYK to the Activated B Cell Receptor Reviewed: Wienands, J, 2012-02-11 The SYK protein tyrosine kinase binds specifically to phosphorylated immunoreceptor tyrosine-activated motifs (ITAMs) on Ig-alpha (CD79A, MB-1) and Ig-beta (CD79B, B29) (Law et al. 1994, Saouaf et al. 1995, Rowley et al. 1995, Tsang et al. 2008). The binding activates the kinase activity of SYK (Rowley et al. 1995, Tsang et al. 2008).