Antigen:p-BCR:p-SYK:p-BLNK BLNK:GRB2:SOS1:CIN85:CBL Antigen:p-BCR:p-SYK Activated SYK Phosphorylates BLNK (SLP65) Authored: May, B, 2010-10-31 BLNK (SLP-65, BASH) forms a stable complex with GRB2, SOS1, and CIN85 in the cytosol. The complex is recruited to the plasma membrane where activated (phosphorylated) SYK phosphorylates BLNK at tyrosines 72, 84, 96, 178, and 189 (Fu et al. 1998, Chiu et al. 2002, inferred from mouse in Wienands et al. 1998, from chicken in Oellerich et al. 2009). Phosphorylated BLNK serves as a scaffold that binds effector molecules such as Phospholipase C. As inferred from mouse, BLNK interacts with phosphorylated tyrosines on CD79A (Ig-alpha) (Engels et al. 2001, Kabak et al. 2002). EC Number: 2.7.10 Edited: May, B, 2010-10-31 Pubmed11071869 Pubmed11449366 Pubmed11909947 Pubmed12456653 Pubmed19372136 Pubmed21822214 Pubmed9341187 Pubmed9697839 Pubmed9705962 Reactome Database ID Release 43983703 Reactome, http://www.reactome.org ReactomeREACT_118834 Reviewed: Wienands, J, 2012-02-11 has a Stoichiometric coefficient of 5