Antigen:p-BCR:p-SYK Antigen:p-BCR:SYK Autophosphorylation of SYK at the Activated BCR Authored: May, B, 2010-09-28 Autophosphorylation of SYK at the Activated B Cell Receptor EC Number: 2.7.10 Edited: May, B, 2010-09-28 Pubmed10648173 Pubmed16849466 Pubmed18006696 Pubmed18052078 Pubmed18818202 Pubmed21469132 Pubmed7538118 Pubmed8163536 Reactome Database ID Release 43983707 Reactome, http://www.reactome.org ReactomeREACT_118728 Reviewed: Wienands, J, 2012-02-11 The SYK protein tyrosine kinase autophosphorylates at tyrosines 131, 323, 348, 352, 525, and 526 (Law et al. 1994, Rowley et al. 1995, Baldock et al. 2000, Irish et al. 2006, Papp et al. 2007, Chen et al. 2008, Tsang et al. 2008). The autophosphorylation increases the kinase activity of SYK. SYK is also phosporylated on additional residues in response to BCR activation (Bohnenberger et al. 2011). has a Stoichiometric coefficient of 6