NF-kappaB:p-IkB:SCF-betaTrCP SCF-beta-TrCp1/2 NF-kappa-B p50/ p65/c-Rel:p-IKB SCF with beta-TrCP1 or beta-TrCP2 Binds NF-kappaB;phospho-IkB Authored: May, B, 2010-12-18 Edited: May, B, 2010-12-18 Pubmed10066435 Pubmed10230406 Pubmed10321728 Pubmed10514424 Pubmed9859996 Pubmed9990852 Reactome Database ID Release 431168642 Reactome, http://www.reactome.org ReactomeREACT_118856 Reviewed: Wienands, J, 2012-02-11 SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) bind IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999).