NF-kappa-B p50,/p65,/c-Rel:IKB NF-kappa-B p50/ p65/c-Rel:p-IKB Phosphorylation of I-kappaB by Activated IKK (B cell) Activated IKK complex phosphorylates the I-kappaB component of the cytoplasmic NF-kappaB complex (Zandi et al. 1998, Burke et al. 1999, Heilker et al. 1999). B cells contain I-kappaB-alpha, I-kappaB-beta, and I-kappaB-epsilon (Whiteside et al. 1997, Li and Nabel 1997). Authored: May, B, 2011-01-19 EC Number: 2.7.11 Edited: May, B, 2011-01-19 Pubmed10593898 Pubmed9135156 Pubmed9315679 Pubmed9721103 Pubmed9914500 Reactome Database ID Release 431168638 Reactome, http://www.reactome.org ReactomeREACT_118618 Reviewed: Wienands, J, 2012-02-11 has a Stoichiometric coefficient of 2