NF-kappaB p50/p65/c-Rel:ub-p-IKB NF-kappaB p50/p65/c-Rel Dimer Degradation of Ubiquitinated IkB (B cell) Authored: May, B, 2010-12-18 Edited: May, B, 2010-12-18 Phosphorylated, ubiquitinated IkB is degraded by the proteasome (Miyamoto et al. 1994, Traenckner et al. 1994, Alkalay et al. 1995, DiDonato et al. 1995, Li et al. 1995, Lin et al. 1995, Scherer et al. 1995, Chen et al. 1995). IkB does not dissociate from NF-kB before it is proteolyzed (Miyamoto et al. 1994, Traenckner et al. 1994, DiDonato et al. 1995, Lin et al. 1995). Pubmed7479848 Pubmed7479976 Pubmed7575604 Pubmed7628694 Pubmed7809113 Pubmed7831327 Pubmed7862124 Pubmed7957109 Reactome Database ID Release 431168640 Reactome, http://www.reactome.org ReactomeREACT_118617 Reviewed: Wienands, J, 2012-02-11