NF-kappaB:p-IkB:SCF-betaTrCP SCF-beta-TrCp1/2 NF-kappaB p50/p65/c-Rel:ub-p-IKB Ubiquitination of IkB by SCF-beta-TrCP Authored: May, B, 2010-12-18 Edited: May, B, 2010-12-18 Pubmed10066435 Pubmed10230406 Pubmed10321728 Pubmed10514424 Pubmed9859996 Pubmed9990852 Reactome Database ID Release 431168643 Reactome, http://www.reactome.org ReactomeREACT_118619 Reviewed: Wienands, J, 2012-02-11 SKP:Cul:F-box (SCF) complexes containing F-box factors Beta-TrCP1 (BTRCP, E3RSIkappaB) or beta-TrCP2 (BTRCP2, FBXW11, HOS) catalyze the polyubiquitination of IkappaB (Yaron et al. 1998, Fuchs et al. 1999, Suzuki et al. 1999, Tan et al. 1999, Winston et al. 1999, Wu and Ghosh 1999). ubiquitin