NF-kappaB p50/p65/c-Rel Dimer NF-kappaB p50/p65/c-Rel Dimer Translocation of NF-kappaB from the Cytosol to the Nucleus Authored: May, B, 2010-12-18 Edited: May, B, 2010-12-18 Nf-kappaB subunits contain nuclear localization sequences and, in the absence of IkB, are translocated to the nucleus (Bauerle and Baltimore 1988, Blank et al. 1991, Ghosh et al. 2008, Fagerlund et al. 2008). c-Rel binds to importins alpha5, alpha6, and alpha7; RelB binds to importins alpha5 and alpha6; p52 binds importin alpha3, alpha4, alpha5, and alpha6 (Fagerlund et al. 2008) Pubmed1756723 Pubmed18462924 Pubmed19066035 Pubmed3129195 Reactome Database ID Release 431168633 Reactome, http://www.reactome.org ReactomeREACT_118705 Reviewed: Wienands, J, 2012-02-11