CARMA1 bound to PDK1 Activated CARMA1 Phosphorylation of CARMA1 Antigen receptor triggered PKC theta dependent linker phosphorylation of S552 residue is required to release this inhibition and expose the CARD motif for downstream Bcl10 recruitment. PDK1 and maybe other unknown adapter proteins bring PKC theta and CARMA1 into close proximity, facilitating PKC theta mediated CARMA1 phosphorylation and consequent activation. Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.11 Pubmed16356853 Pubmed17468049 Reactome Database ID Release 43202437 Reactome, http://www.reactome.org ReactomeREACT_12573 Reviewed: Trowsdale, J, 2008-02-26 12:02:59