MALT1 trimer bound to Bcl10 and CARMA1 trimer MALT1 trimer Bcl10 trimer bound to CARMA1 trimer Interaction and oligomerization of MALT1 to Bcl10 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Oligomerized Bcl10 facilitates the association with MALT1 to form the CBM signalosome. MALT1 possesses one death domain (DD) and 2 immunoglobulin-like domains (Ig-like) in its N-terminal region and a caspase like domain (CLD) in its C-terminal region. The region between amino acids 107 and 119 of Bcl10 bind to the two Ig-like domains of MALT1. After binding to CARMA1 and Bcl10 complex, MALT1 also undergoes oligomerization. Only the oligomerized forms of Bcl10 and MALT1 are capable of activating IKK. Pubmed15125833 Reactome Database ID Release 43202478 Reactome, http://www.reactome.org ReactomeREACT_12563 Reviewed: Trowsdale, J, 2008-02-26 12:02:59