Bcl10 bound to CARMA1 Phosphorylated Bcl10 bound to CARMA1 and RIP2 Phosphorylation of Bcl10 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.11 Pubmed17468049 Reactome Database ID Release 43202459 Reactome, http://www.reactome.org ReactomeREACT_12619 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Upon interaction with CARMA1, Bcl10 undergoes phosphorylation and oligomerization. The oligomerized Bcl10 acts as a adaptor for the incoming MALT1 and TRAF6. Phosphorylation events of Bcl10 can both positively and negatively regulate the NF-kB pathway. Phosphorylation of Bcl10 that depends on the Ser/Thr kinase RIP2 and correlated with the physical association of Bcl10 with RIP2 has a activation effect on the NF-kB pathway. The target sites of RIP2-mediated phosphorylation has not yet been identified.