PKC theta (opened conformation) bound to DAG Active PKC theta bound to DAG Phosphorylation of PKC theta Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.11 Pubmed12473184 Pubmed16978534 Raft localized PKC theta is further phosphorylated and activated by PDK1. The threonine residue (T538) in the kinase domain is the potential target of PDK1. Phosphorylation of this site is critical for the PKC theta kinase activity, and its ability to activate NF-kB pathway. PKC theta is later trans-autophopshorylated on putative phosphorylation sites (S676, S695) for the fine-tuning of its kinase activity. Reactome Database ID Release 43202222 Reactome, http://www.reactome.org ReactomeREACT_12557 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 3