K63-polyubiquitin TRIKA1 IKK complex with Ub-NEMO IKK complex with phosphorylated IKK beta Ubiquitination of NEMO by TRAF6 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 During the phosphorylation of the IKK beta, the regulatory subunit NEMO undergoes K-63-linked polyubiquitination. Ubiquitinated TRAF6 trimer, acts as a E3 ligase and induces this ubiquitination. The ubiquitin target sites in NEMO are not yet clearly identified. Residues Lysine 321 and Lysine 326 may be few of the potent ubiquitination sites in NEMO. EC Number: 6.3.2.19 Pubmed17047224 Pubmed17728323 Reactome Database ID Release 43202534 Reactome, http://www.reactome.org ReactomeREACT_12553 Reviewed: Trowsdale, J, 2008-02-26 12:02:59