TAB2/TAK1 complex TAK1/TAB2 complex bound to TRAF6/CBM complex Ub-TRAF6 trimer bound to CBM complex Activation of TAK1-TAB2 complex Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.11 Pubmed15125833 Pubmed16056267 Pubmed17496917 Reactome Database ID Release 43202510 Reactome, http://www.reactome.org ReactomeREACT_12518 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 Ubiquitinated TRAF6 recruits TAB2 and activates the TAB2-associated TAK1 kianse by promoting the autophosphorylation of TAK1. TAB2 contains an N-term pseudophosphatase domain, which is indispensable for TAK1 activation, and a C-term domain that binds to and activates TAK1. The activation of TAK1/TAB2 complex requires a ubiquitination reaction catalysed by E1, Ubc13/Uev1A (E2) and TRAF6 (E3). TAK1 undergoes autophosphorylation on residues T184 and T187 and gets activated. Activated TAK1 then phosphorylates and activates IKK beta. has a Stoichiometric coefficient of 2