CD28:Grb2 phospho CD28:B7-1/B7-2 Grb2 binds CD28 Authored: Garapati, P V, 2008-12-16 11:12:19 CD28 is capable of binding the Src homology 3 (SH3) domains of several proteins, including Grb2. The phospho-YMNM motif in CD28's cytoplasmic domain facilitates tandem SH2–SH3 domain binding. Grb-2 has been shown to bind to the CD28 YMNM motif with additional SH3 domain binding to the diproline motif in the C-terminal portion of the cytoplasmic domain of CD28. Edited: Garapati, P V, 2008-12-16 11:12:19 Pubmed7737275 Pubmed9694876 Reactome Database ID Release 43388814 Reactome, http://www.reactome.org ReactomeREACT_19254 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33