SHP-1/SHP-2 bound to phospho PD-1 Phosphorylated PD-1 bound to B7DC/B7H1 Interaction of SHP-1 or SHP-2 with phospho PD-1 Authored: Garapati, P V, 2008-12-16 11:12:19 Edited: Garapati, P V, 2008-12-16 11:12:19 Once phosphorylated, SH2-domain containing tyrosine phosphatases SHP-1 and SHP-2 bind to the ITIM and ITSM motifs of PD-1. The association between SHP-1 and PD-1 appears to be weaker than the interaction of PD-1 with SHP-2. Pubmed18173375 Pubmed18759926 Reactome Database ID Release 43389759 Reactome, http://www.reactome.org ReactomeREACT_19198 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33 SHP-2/SHP-1