pCTLA-4:Src kinases:SHP2 Phosphorylated CTLA-4 bound to kinases SHP2 phosphatase binds CTLA-4 Authored: Garapati, P V, 2008-12-16 11:12:19 CTLA4 associates with the SH2 domain containing tyrosine phosphatase SHP2 and this interaction is mediated through the YVKM motif of CTLA-4. Phosphorylation of tyrosine in the YVKM motif recruits SHP-2. <br>Still the association of SHP-2 with CTLA-4 is unclear and remains controversial. Several other studies have reported that CTLA-4 does not directly associate with SHP-2. The interaction between the phosphatase and CTLA-4 may be an indirect event, possibly mediated by PI3-kinase/SHP-2 binding. Edited: Garapati, P V, 2008-12-16 11:12:19 Pubmed10694513 Pubmed9712716 Reactome Database ID Release 43388829 Reactome, http://www.reactome.org ReactomeREACT_19203 Reviewed: Bluestone, JA, Esensten, J, 2009-06-01 18:47:33