GADS:p-5Y-LAT Recruitment of Gads to LAT Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Gads is a member of the Grb2 family containing SH2 and SH3 domains with the arrangement SH3-SH2-SH3. Gads binds to the tyrosine phosphorylated residues Y171 and Y191 of LAT through its SH2 domain. It plays a critical role in signaling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT. Pubmed11607830 Reactome Database ID Release 43202325 Reactome, http://www.reactome.org ReactomeREACT_12570 Reviewed: Trowsdale, J, 2008-02-26 12:02:59