GADS:p-5Y-LAT SLP-76 bound to Gads:LAT Recruitment of SLP-76 to Gads Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 Pubmed11607830 Reactome Database ID Release 43202241 Reactome, http://www.reactome.org ReactomeREACT_12489 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 SLP-76 is an adaptor protein that links proximal and distal T cell receptor signaling events through its function as a molecular scaffold in the assembly of multi molecular signaling complexes. SLP-76 consists of three domains that mediate interactions with many different signaling proteins: an N-terminal acidic domain containing three tyrosine phosphorylation sites, a large central proline-rich region, and a C-terminal SH2 domain. The function of SLP-76 is dependent on its association with Gads. SLP-76 constitutively binds through its 'RxxK' motif in the proline rich region to the SH3 domain of Gads upon TCR activation.