p-Y113,Y128,Y145-SLP-76:Gads: LAT PLCG1:p-3Y-SLP-76:Gads:LAT Recruitment of PLC-gamma1 to SLP-76 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 PLC-gamma1 plays an important role in transducing the external signal in to second messengers by hydrolysing PIP2. PLC-gamma1 contains an N-term PH domain, a catalytic domain 'X' followed by two SH2 domains and an SH3 domain, a C-term catalytic domain 'Y' and a C2 domain (Ca++ binding). PLC-gamma1 interacts with both SLP-76 aswell as LAT. It interacts with its SH3 domain to the proline rich sequence of SLP-76. This interaction aids in localizing PLC-gamma1 to the membrane. This recruitment of PLC-gamma1 to LAT and SLP-76 is essential for its TCR induced tyrosine phosphorylation and activation. Pubmed11048639 Pubmed11390650 Reactome Database ID Release 43202331 Reactome, http://www.reactome.org ReactomeREACT_12506 Reviewed: Trowsdale, J, 2008-02-26 12:02:59