SLP-76 bound to Gads:LAT p-Y113,Y128,Y145-SLP-76:Gads: LAT Phosphorylation of SLP-76 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.10 Once SLP-76 is recruited to Gads its rapidly phosphorylated on the tyrosine residues in the N-terminal acidic domain. This domain contains three tyrosine phosphorylation sites, Y113, Y128 and Y145. These tyrosine residues are phosphorylated by tyrosine kinase ZAP-70 and these phosphorylated tyrosine residues provide the binding site for the SH2 domains of the incoming signaling proteins like Vav, Itk and PLC-gamma1. Pubmed17652306 Reactome Database ID Release 43202216 Reactome, http://www.reactome.org ReactomeREACT_12615 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 has a Stoichiometric coefficient of 3