PI3K phosphorylates PIP2 to PIP3 Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 EC Number: 2.7.1.153 PI3K enzyme bound to adaptor protein TRIM, uses phosphatidylinositol 4,5-bisphosphate (PIP2) as its substrate and phosphorylates it to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). This PIP3 acts as a membrane anchor for the downstream proteins like PDK1 and PKB. Pubmed12660731 Reactome Database ID Release 43202365 Reactome, http://www.reactome.org ReactomeREACT_12561 Reviewed: Trowsdale, J, 2008-02-26 12:02:59