PDK1 bound to either PIP3 or PI(3,4)P2 Translocation of PDK1 to Plasma membrane Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10 PDK1 is a Ser/Thr kinase with a N-term kinase domain and a C-term PH domain. PDK1 with its PH domain binds to PIP3 and PI(3,4)P2 and is translocated to the plasma membrane. PDK1 seems to exist in an active, phosphorylated configuration under basal conditions. PDK1 pays an important role in activating and phosphorylating the enzymes PKB and PKC theta. Pubmed10698680 Reactome Database ID Release 43202164 Reactome, http://www.reactome.org ReactomeREACT_12641 Reviewed: Trowsdale, J, 2008-02-26 12:02:59 PIP3, PI(3,4)P2