PathwayStep4493 PathwayStep4492 PathwayStep4495 PathwayStep4494 MAD2 converted to an inhibitory state via interaction with Mad1 MAD2 associates with the Mad1 kinetochore complex Release of activated MAD2 from kinetochores Mad1 binds kinetochore Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Authored: Yen, T, 2004-05-05 00:00:00 Pubmed14593737 Reactome Database ID Release 43141444 Reactome, http://www.reactome.org ReactomeREACT_491 The signal from unattached kinetochores is amplified through a Mad2 inhibitory signal that is propagated by the binding of Mad1 to the kinetochore, the association of Mad2 with Mad1, the conversion of Mad2 conformation to an inhibitory form through its association with Mad1 and finally the release of the inhibitory form of Mad2 from the kinetochore.