Interaction of PAK-2p34 with RGH10/ PS-GAP results in accumulation of PAK-2p34 in the perinuclear region Rho GTPase-activating protein 10 (RHG10) interacts with caspase-activated PAK-2p34 PathwayStep4435 PathwayStep4434 Regulation of PAK-2p34 activity by PS-GAP/RHG10 Authored: Jakobi, R, 2008-02-05 11:04:14 Edited: Matthews, L, 2008-02-03 20:50:13 Edited: Matthews, L, 2008-06-12 00:23:53 PS-GAP (RGH10) interacts specifically with caspase-activated PAK-2p34 reducing the ability of PAK-2p34 to induce cell death. This interaction  inhibits the kinase activity of  PAK-2p34 and changes the localization of PAK-2p34 from the nucleus to the perinuclear region (Koeppel et al., 2004).   Pubmed15471851 Reactome Database ID Release 43211728 Reactome, http://www.reactome.org ReactomeREACT_13528 Reviewed: Chang, E, 2008-05-21 00:05:41