PathwayStep4460 p53-Dependent G1/S DNA damage checkpoint Authored: Khanna, K, 2003-06-05 08:03:38 Edited: Joshi-Tope, G, 0000-00-00 00:00:00 Pubmed1323840 Reactome Database ID Release 4369580 Reactome, http://www.reactome.org ReactomeREACT_85 The arrest at G1/S checkpoint is mediated by the action of a widely known tumor suppressor protein, p53. Loss of p53 functions, as a result of mutations in cancer prevent the G1/S checkpoint (Kuerbitz et al, 1992). P53 is rapidly induced in response to damaged DNA. A number of kinases, phosphatases, histone acetylases and ubiquitin-conjugating enzymes regulate the stability as well as transcriptional activity of p53 after DNA damage. p53-Dependent G1 DNA Damage Response