Dissociation of the COP1-p53 complex Translocation of COP1 from the nucleus to the cytoplasm Phosphorylation of COP1 at Ser-387 by ATM Autoubiquitination of phospho-COP1(Ser-387 ) Proteasome mediated degradation of COP1 PathwayStep4449 PathwayStep4452 PathwayStep4453 PathwayStep4450 PathwayStep4451 Autodegradation of the E3 ubiquitin ligase COP1 Authored: Matthews, L, 2008-06-12 21:09:06 COP1 is one of several E3 ubiquitin ligases responsible for the tight regulation of p53 abundance. Following DNA damage, COP1 dissociates from p53 and is inactivated by autodegradation via a pathway involving ATM phosphorylation of COP1 on Ser(387), autoubiquitination and proteasome mediated degradation. Destruction of COP1 results in abrogation of the ubiquitination and degradation of p53 (Dornan et al., 2006). Edited: Matthews, L, 2009-11-09 Pubmed16931761 Reactome Database ID Release 43349425 Reactome, http://www.reactome.org ReactomeREACT_20549 Reviewed: Dixit, VM, 2009-11-17