L-selectin interacting with known ligands L-selectin ligands Ligands bind L-selectin Authored: de Bono, B, 2007-07-08 12:58:15 L-selectin plays a major role in leukocyte traffic through lymph node high endothelial venules.<p><p>Both MAdCAM and GlyCAM-1 are major L-selectin ligands produced by these venules and mediate leukocyte rolling, particularly in lymphocytes. They are also expressed in mammary tissue and play an important role in the transfer of immune cells into milk secretions.<p><p>The adhesive properties of CD34 and its potential role in homing lymphocytes to lymphoid tissues mimics the mechanims leukocytes adopt to travel to inflammatory sites. Pubmed12588680 Pubmed16846369 Pubmed9865468 Reactome Database ID Release 43199046 Reactome, http://www.reactome.org ReactomeREACT_11230 Reviewed: Trowsdale, J, 2007-08-06 19:33:04