CD200 bound to CD200R CD200 binds to CD200R Authored: de Bono, B, 2007-07-08 12:58:15 Pubmed15187158 Pubmed16928187 Reactome Database ID Release 43199154 Reactome, http://www.reactome.org ReactomeREACT_11188 Reviewed: Trowsdale, J, 2007-08-06 19:33:04 While not ubiquitously distributed, CD200 is expressed on a wide range of cell types including thymocytes, B-cells, activated T-cells, follicular dendritic cells, endothelium, CNS neurons in the central nervous system, cells in reproductive organs, keratinocytes and renal glomeruli. CD200R is a myeloid-inhibitory receptor, despite the absence of classical ITIMs in the cytoplasmic portion of the protein. Interestingly, CD200 is also expressed on neurons within the CNS and would be predicted to modulate activation of microglia through CD200R.