14-3-3 beta, zeta p(S7)-Rap1 GTPase-activating protein 2:14-3-3beta, zeta 14-3-3 proteins beta and zeta bind and inhibit Rap1Gap2 Authored: Akkerman, JW, 2009-06-03 Edited: Jupe, S, 2010-09-01 Pubmed15632203 Pubmed18039662 RAP1GAP2 binds 14-3-3 proteins beta and zeta, inhibiting its GAP activity for Rap1. This effect is diminished by Ser-7 phosphorylation of RAP1GAP2 by cGMP- and cAMP-dependent protein kinases (PKG and PKA respectively), which inhibits the binding of 14-3-3 proteins beta and zeta to Rap1GAP2. 14-3-3 binding does not appear to alter the GTPase-activating function of Rap1GAP2 in vitro, but attenuates Rap1GAP2 mediated inhibition of cell adhesion (Hoffmeister et al. 2008). Reactome Database ID Release 43913993 Reactome, http://www.reactome.org ReactomeREACT_23924 Reviewed: Heemskerk, JW, 2010-09-01