Nonameric complex MHC class II alpha/beta/Ii nonamer Transport of MHC II:Ii complex to plasma membrane Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 Pubmed10540230 Pubmed14731593 Pubmed15911768 Pubmed16824007 Pubmed8397411 Reactome Database ID Release 432130378 Reactome, http://www.reactome.org ReactomeREACT_121019 Reviewed: Neefjes, Jacques, 2012-05-14 The newly formed MHC II-Ii complex exits the TGN and ultimately is delivered to late-endosome/lysosome compartments. A proportion of the nonameric complex traffics directly from the TGN to these compartments, while a substantial population follow the indirect pathway involving transport from the TGN to the plasma membrane, followed by endocytic delivery to early endosomes, late endosomes, and finally lysosomes (McCormick et al. 2005). Transport carrier vesicles may traffic the cargo MHC II-Ii complex from the TGN to the plasma membrane.