Antigen Antigen MHC class II antigen internalization Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 MHC II typically presents antigens derived from exogenous proteins internalized by APCs such as macrophages, B cells or dendritic cells. Different types of antigen use different routes of internalization. Endocytosis may be specific, mediated by a range of receptors expressed on APC, or may occur by nonspecific mechanisms such as phagocytosis, macropinocytosis or autophagy. Antigens are first loaded into endocytic vesicles and progress along the early endosomes (EE)-late endosomes (LE) lysosomal axis. Antigens are exposed to increasingly acidic, more denaturing and proteolytic conditions (Doherty & McMahon 2009, Underhill & Ozinsky 2002). Pubmed10092778 Pubmed11714749 Pubmed11861619 Pubmed19317650 Pubmed8970738 Reactome Database ID Release 432130627 Reactome, http://www.reactome.org ReactomeREACT_121145 Reviewed: Neefjes, Jacques, 2012-05-14