Antigen peptide bound class I MHC TCR interacting with antigen-bearing MHC Class I T-cell receptor complex with CD8 TCR complex interacts with peptide antigen-presenting MHC Class I Authored: de Bono, B, 2007-07-08 12:58:15 Pubmed15136729 Pubmed15534202 Pubmed16551255 Reactome Database ID Release 43198955 Reactome, http://www.reactome.org ReactomeREACT_11080 Reviewed: Trowsdale, J, 2007-08-06 19:33:04 T cells distinguish foreign material from self through presentation of fragments of the antigen by the MHC cell surface receptors. Only if an MHC molecule presents an appropriate antigenic peptide will a cellular immune response be triggered. The orchestration of recognition and signaling events, from the initial recognition of antigenic peptides to the lysis of the target cell, is performed in a localized environment on the T cell, called the immunological synapse, and requires the coordinated activities of several T-Cell Receptor (TCR)-associated molecules. This particular reaction depicts the interaction of the TCR with MHC Class I molecules on somatic cell, requiring the support of CD3 and CD8 proteins.