Nonameric complex Nonameric complex in COPII vesicle Sar1b:GTP:Sec23p:Sec24p:Sec13p:Sec31p Complex Formation of COPII vesicle Authored: Garapati, P V, 2012-02-21 Edited: Garapati, P V, 2012-02-21 Immediately after assembly in the ER nonameric (alpha beta:Ii)3 complexes egress from ER, facilitated by the presence of Ii, and enter the Golgi complex (Wolf & Ploegh 1995, Geuze 1998). Incorrectly folded or oligomerized alpha, beta and Ii chains are retained in the ER and degraded. The Sec23/24-Sar1 pre-budding complex binds to the nonameric complex and then recruits Sec13/31 outer shell, which buds off from the membrane as a coat protein complex II (COPII) vesicle to be transported to the Golgi complex (Bickford et al. 2004). Pubmed11790530 Pubmed15093828 Pubmed19703008 Pubmed2391366 Pubmed8689559 Pubmed9639994 Reactome Database ID Release 432130731 Reactome, http://www.reactome.org ReactomeREACT_120802 Reviewed: Neefjes, Jacques, 2012-05-14