COPII vesicle with MHC class I Antigen peptide bound class I MHC Sar1b:GDP Complex Disassembly of COPII coated vesicle Authored: Garapati, P V, 2010-10-29 Before the cargo vesicle can fuse with target membrane, the COPII protein coat must be disassembled and its components released into cytosol. This uncoating is triggered by hydrolysis of the bound GTP to produce Sar1p-GDP, which has decreased affinity for the vesicle membrane. Disassociation of Sar1p-GDP from the membrane is followed by the release of the other COPII subunits. EC Number: 3.6.5.1 EC Number: 3.6.5.2 EC Number: 3.6.5.3 EC Number: 3.6.5.4 Edited: Garapati, P V, 2010-10-29 Pubmed10825291 Pubmed10982397 Pubmed17316621 Reactome Database ID Release 43983422 Reactome, http://www.reactome.org ReactomeREACT_75799 Reviewed: Elliott, T, 2011-02-10 Sec24